A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023.

Massimiliano Fabricci, Anaïs Trinca, Luca Talotti,Marina Busetti, Emmanouil Alexandros Fotakis,Christina Merakou,Raffaella Koncan, Annachiara Ghiotti, Camilla Negri, Vittorio Di Maso, Manuela Bosco,Alberto Antonelli,Marco Coppi,Gian Maria Rossolini, Claudia Giuliani,Enrico Scarpis, Barbara Gregoretti,Danilo Licastro,Roberto Luzzati, Venera Costantino

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin（2023）

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摘要

An outbreak of bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with infections (attack rate = 34%; 95% confidence interval: 22.1-47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

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关键词

ralstonia mannitolilytica bloodstream infections,haemodialysis patients,outbreak,urokinase-associated,north-eastern

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