Pd28-02 treatment of non-obstructing kidney stones in patients for flank pain: prospective multicenter trial: a core initiative

You have accessJournal of UrologyCME1 Apr 2023PD28-02 TREATMENT OF NON-OBSTRUCTING KIDNEY STONES IN PATIENTS FOR FLANK PAIN: PROSPECTIVE MULTICENTER TRIAL: A CORE INITIATIVE Naeem Bhojani, Daniel Wollin, Marawan El Tayeb, Kymora Scotland, John Knoedler, Karen L. Stern, David-Dan Nguyen, Marcelino Rivera, Michael Borofsky, Noah E. Canvasser, Seth Bechis, and Ryan S Hsi Naeem BhojaniNaeem Bhojani More articles by this author , Daniel WollinDaniel Wollin More articles by this author , Marawan El TayebMarawan El Tayeb More articles by this author , Kymora ScotlandKymora Scotland More articles by this author , John KnoedlerJohn Knoedler More articles by this author , Karen L. SternKaren L. Stern More articles by this author , David-Dan NguyenDavid-Dan Nguyen More articles by this author , Marcelino RiveraMarcelino Rivera More articles by this author , Michael BorofskyMichael Borofsky More articles by this author , Noah E. CanvasserNoah E. Canvasser More articles by this author , Seth BechisSeth Bechis More articles by this author , and Ryan S HsiRyan S Hsi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003313.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pain associated with renal stone disease is typically caused by an obstructive stone resulting in renal collecting system dilatation. However, a number of retrospective studies have examined pain associated with non-obstructing kidney stones and have suggested that their removal is associated with improvement in symptoms. We performed a multicenter prospective study to determine if the removal of small non-obstructing renal calculi can reduce a patient’s pain and/or improve their quality of life. METHODS: We identified patients with small non-obstructing kidney stones (≤10 mm maximum length; measured via CT) with associated moderate to severe flank pain (≥5 on pain scale). Exclusion criteria included ipsilateral hydronephrosis and nephrocalcinosis. Once all other causes of the pain were clinically ruled out, these patients underwent ureteroscopy (URS) and kidney stone treatment (08/2018-08/2022). Brief Pain Inventory (BPI) and the Wisconsin Stone Quality of Life questionnaire (WISQOL) were completed pre-operatively, and post-operatively at 2, 6, and 12 weeks. A clinically significant decrease in BPI score is 20% was considered the primary study endpoint. All patients underwent 6-8 weeks post-operative imaging to determine stone free status. RESULTS: A total of 42 patients with small non-obstructing kidney stones with associated flank pain were recruited at 10 sites across North America. From BPI scores, mean pain and worst pain was 5.5 and 7.2 respectively preoperatively; 2.9 and 4.7 respectively at 2 weeks postoperatively; 1.8 and 2.8 respectively at 6 weeks; and 1.8 and 2.8 respectively at 12 weeks post op (Figure 1). WISQOL mean score increased from 70.4 preoperatively to 115.3 at 12 weeks postoperatively (Figure B). A total of 86% and 69% of patients had at least a 20% and 50% reduction in their average pain scores at 12 weeks postoperatively, respectively. A total of 75% and 61% of patients had at least a 20% and 50% reduction in their worst pain scores at 12 weeks postoperatively, respectively. CONCLUSIONS: In selected patients with non-obstructing calyceal stones and associated flank pain, stone removal decreases pain and improves kidney stone health-related quality of life. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e818 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Naeem Bhojani More articles by this author Daniel Wollin More articles by this author Marawan El Tayeb More articles by this author Kymora Scotland More articles by this author John Knoedler More articles by this author Karen L. Stern More articles by this author David-Dan Nguyen More articles by this author Marcelino Rivera More articles by this author Michael Borofsky More articles by this author Noah E. Canvasser More articles by this author Seth Bechis More articles by this author Ryan S Hsi More articles by this author Expand All Advertisement PDF downloadLoading ...