Pd18-05 idiopathic secondary azoospermia occurrence in infertile men over time

You have accessJournal of UrologyCME1 Apr 2023PD18-05 IDIOPATHIC SECONDARY AZOOSPERMIA OCCURRENCE IN INFERTILE MEN OVER TIME Gilad Karavani, Kirk C. Lo, Ethan D. Grober, Mohamed S. Kattan, Susan Lau, and Keith Jarvi Gilad KaravaniGilad Karavani More articles by this author , Kirk C. LoKirk C. Lo More articles by this author , Ethan D. GroberEthan D. Grober More articles by this author , Mohamed S. KattanMohamed S. Kattan More articles by this author , Susan LauSusan Lau More articles by this author , and Keith JarviKeith Jarvi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003273.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: While the occurrence of azoospermia in the male population and its risk factors are well studied, only scarce data exists on the unique group of patients without known risk factors for sperm quality deterioration who eventually develop idiopathic secondary azoospermia (ISA). Early identification of such cases will allow interventions to preserve fertility by sperm banking. This study aimed to investigate the occurrence of ISA with time in men with initial oligospermia to identify those with higher risk of becoming azoospermic. METHODS: This was a retrospective cohort study from a single university-affiliated male infertility clinic. Patients that had at least two semen analyses (SA) 3 months or more apart between 2005 and 2021 were included. Patients with normal sperm concentration (above 15 million/ml), those with risk factors for deterioration in semen quality (chemo-radiotherapy exposure, Kleinfelter syndrome, etc.) and those with an initial semen analyses showing azoospermia, were excluded. Patients were allocated to three groups according to their initial sperm concentration – ≤1, 1-5 and 5-15 million/ml. Basic characteristics as well as the first and last SA and hormonal levels were compared between the groups. The primary outcome was the occurrence of ISA in each group with time. RESULTS: Overall, 1044 patients with two SA and no other known risk factors were included in the analysis. Thirty-one patients (3.0%) eventually became azoospermic with time. The ≤1 million/ml group (280 patients) had significantly higher rates of ISA in each time period compared to the 1-5 million/ml (312 patients) and 5-15 million/ml (452 patients) group (p<0.005 for all comparisons). CONCLUSIONS: The group of men with ≤1 million/mL have a dramatically increased chances of becoming azoospermic with time, reaching a peak of over 25% after 3 years. Therefore, sperm banking should be recommended, as early as possible, in case of extremely severe oligospermia. Men with sperm counts > 1million/mL could be counseled that their chances of ISA are low, even after 3 or more years. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e504 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gilad Karavani More articles by this author Kirk C. Lo More articles by this author Ethan D. Grober More articles by this author Mohamed S. Kattan More articles by this author Susan Lau More articles by this author Keith Jarvi More articles by this author Expand All Advertisement PDF downloadLoading ...