Effect of gender on survival outcomes after trimodal therapy for muscle-invasive bladder cancer

You have accessJournal of UrologyCME1 Apr 2023PD44-02 EFFECT OF GENDER ON SURVIVAL OUTCOMES AFTER TRIMODAL THERAPY FOR MUSCLE-INVASIVE BLADDER CANCER Iain Macintyre, Ronald Kool, Gautier Marcq, Rodney Breau, Bobby Shayegan, Michael Kim, Ionut Busca, Hamidreza Abdi, Mark Dawidek, Michael Uy, Gagan Fervaha, Fabio Cury, Nimira Alimohamed, Johnathan Izawa, Claudio Jeldres, Ricardo Rendon, Peter Black, Girish Kulkarni, Wassim Kassouf, and D. Robert Siemens Iain MacintyreIain Macintyre More articles by this author , Ronald KoolRonald Kool More articles by this author , Gautier MarcqGautier Marcq More articles by this author , Rodney BreauRodney Breau More articles by this author , Bobby ShayeganBobby Shayegan More articles by this author , Michael KimMichael Kim More articles by this author , Ionut BuscaIonut Busca More articles by this author , Hamidreza AbdiHamidreza Abdi More articles by this author , Mark DawidekMark Dawidek More articles by this author , Michael UyMichael Uy More articles by this author , Gagan FervahaGagan Fervaha More articles by this author , Fabio CuryFabio Cury More articles by this author , Nimira AlimohamedNimira Alimohamed More articles by this author , Johnathan IzawaJohnathan Izawa More articles by this author , Claudio JeldresClaudio Jeldres More articles by this author , Ricardo RendonRicardo Rendon More articles by this author , Peter BlackPeter Black More articles by this author , Girish KulkarniGirish Kulkarni More articles by this author , Wassim KassoufWassim Kassouf More articles by this author , and D. Robert SiemensD. Robert Siemens More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003354.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There are well demonstrated gender- and sex-based influences on bladder cancer incidence, stage at presentation and, potentially, therapeutic outcomes. Less clear is whether, stage for stage, there are differential outcomes between women and men with muscle invasive bladder cancer (MIBC) treated for cure. The purpose of this study is to examine whether there are gender-related differences in survival outcomes for those patients treated with trimodal therapy (TMT) for MIBC. METHODS: This retrospective, multi-center study reports on 542 patients that underwent curative intent radiotherapy with concurrent chemotherapy, for MIBC across academic centers in Canada. Survival outcomes, including overall survival (OS) and cancer specific survival (CSS), were estimated using the Kaplan-Meier method. Multivariable regression models were performed to explore independent predictors of survival outcomes. RESULTS: There were 397 men and 145 women who underwent trimodal therapy for MIBC across the participating centers with a total median follow-up 30 months [95% CI 27-32]. There were no clinically significant gender-related differences in baseline cancer characteristics or treatment specifics identified. Median OS for men was 81 months, [95% CI 71 – 95] versus women 52 months, [95% CI 52 – 154]. Median CSS for men was not reached, [95% CI not reached] versus women 129 months, [95% CI 72-not reached]. Median disease free survival for men was 28 months, [95% CI 22 – 44] versus women 29 months, [95% CI 18 – 52]. In multivariable analysis, gender 1.41 [95% CI 1.02-1.95, p=0.035] was associated with OS favouring men, although no differences were observed for CSS. ECOG performance status, tumour stage, presence of hydronephrosis, and RT volume were all independently associated with both CSS and OS in multivariable analysis. CONCLUSIONS: Similar to previous findings suggesting gender-related differences in the management and outcomes of patients with MIBC treated with cystectomy, this large cohort multi-center study did demonstrate some differences in survival outcomes between men and women amongst those receiving TMT. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1124 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Iain Macintyre More articles by this author Ronald Kool More articles by this author Gautier Marcq More articles by this author Rodney Breau More articles by this author Bobby Shayegan More articles by this author Michael Kim More articles by this author Ionut Busca More articles by this author Hamidreza Abdi More articles by this author Mark Dawidek More articles by this author Michael Uy More articles by this author Gagan Fervaha More articles by this author Fabio Cury More articles by this author Nimira Alimohamed More articles by this author Johnathan Izawa More articles by this author Claudio Jeldres More articles by this author Ricardo Rendon More articles by this author Peter Black More articles by this author Girish Kulkarni More articles by this author Wassim Kassouf More articles by this author D. Robert Siemens More articles by this author Expand All Advertisement PDF downloadLoading ...