Combining polygenic risk scores and human leukocyte antigen variants for personalized risk assessment of type 1 diabetes in the Taiwanese population.

Wen-Ling Liao,Yu-Nan Huang,Ya-Wen Chang,Ting-Yuan Liu,Hsing-Fang Lu,Zih-Yu Tiao,Pen-Hua Su,Chung-Hsing Wang,Fuu-Jen Tsai

Diabetes, obesity & metabolism（2023）

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摘要

Polygenic risk score and HLA variations enable personalized risk estimates, enhance newborn screening efficiency for ketoacidosis prevention, and addresses the gap in data on T1D prediction in isolated Asian populations.

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关键词

clinical event, electronic medical record, genome-wide association studies, human leukocyte antigen, polygenic risk scores, type 1 diabetes

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