Choice of the optimal synthetic approach for the polypeptide ligands of prostatic specific membrane antigen preparation
Mendeleev Communications(2023)
摘要
Two alternative synthetic schemes involving solid-phase peptide synthesis steps for the preparation of prostatic specific membrane antigen ligands based on Glu-Urea-Lys with peptide fragments in the linker structure are compared. In the first approach, the amino acid key intermediate is attached to the 2-CTC resin by the carboxy group while in the second approach, by the amino one. The preference for each approach is dependent on the particular target molecule
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关键词
solid -phase peptide synthesis, prostatic specific membrane antigen, prostate cancer, targeted delivery, anticancer drugs
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