Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis.

Xia Xu,Haiwen Lu,Jianxiong Li,Jielin Duan, Zhongwei Wang,Jiawei Yang,Shuyi Gu, Rongguang Luo,Shuo Liang,Wei Tang,Fengying Zhang,Jingqing Hang,Juan Ge,Xin Lin,Jieming Qu,Xinming Jia,Jinfu Xu

Chinese medical journal（2023）

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摘要

Our study provides the genetic evidence showing that the heterozygous mutation of CARD9S12N, followed by allele expression imbalance of CARD9S12N, facilitates the development of ABPA.

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