Leukocyte Ig-like receptor A3 facilitates inflammation, migration and invasion of synovial tissue-derived fibroblasts via ERK/JNK activation.

Mengru Liu,Yundi Tang,Yan Du,Jing Zhang,Fanlei Hu,Yundong Zou,Yingni Li,Lei Zhu,Jing He,Jianping Guo,Zhanguo Li

Rheumatology (Oxford, England)（2023）

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摘要

The present study provides the first evidence that soluble LILRA3 is a novel proinflammatory mediator involved in synovial inflammation by promoting RA-FLS activation, migration and invasion, probably through the ERK/JNK signalling pathways.

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关键词

leukocyte immunoglobulin-like receptor A3, RA, fibroblast-like synoviocyte, ERK and JNK signalling

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