A d-peptide-based oral nanotherapeutic modulates the PD-1/PD-L1 interaction for tumor immunotherapy.

Dan Liu,Jingmei Wang,Weiming You,Fang Ma,Qi Sun,Junjun She,Wangxiao He,Guang Yang

Frontiers in Immunology（2023）

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摘要

This study has successfully designed and synthesized an oral nanotherapeutic, PDL1, which demonstrates small particle size, excellent colloidal stability, transmembrane ability in tumor cells, and biocompatibility. experiments have shown that it effectively activates T-cell immunity and exerts antitumor effects.

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关键词

immunotherapy,peptide,supramolecular nanospheres,milk exosome,anti-tumor

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