A common variant in the hepatobiliary phospholipid transporter modulates liver injury in PBC but not in PSC

Background Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) represent two chronic cholestatic liver diseases. The ABCB4 gene encodes the hepatobiliary phospholipid transporter and its genetic defects cause cholestatic phenotypes (Stättermayer et al., J Hepatol. 2020). Here we investigate the ABCB4 c.711A-T genetic variant in patients with PBC and PSC.