Preoperative chemotherapy prior to primary tumour resection for asymptomatic synchronous unresectable colorectal liver-limited metastases: The RECUT multicenter randomised controlled trial

•It was the first RCT to evaluate the PFS of pre-PTR chemotherapy for CRLMs.•Pre-PTR chemotherapy improved the PFS compared with upfront PTR.•This trial provided evidence to confirm the advantages of pre-PTR chemotherapy.