Analysis of intercellular communication in the osteosarcoma microenvironment based on single cell sequencing data

•OS microenvironment displays heterogeneity in cellular composition and myeloid cells were the most commonly represented cell type.•Oosteoclasts in the OS microenvironment could be differentiated from myeloid cells.•Co-expression of receptors and ligands for intercellular communication is associated with patient prognosis.•Intercellular communication differs in tumor microenvironment of OS patients received chemotherapy or not.