RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.

Xufei Zhang,Jie Wu,Qinjie Liu,Xuanheng Li,Yiyu Yang,Lei Wu,Xiuwen Wu,Yun Zhao,Jianan Ren

Clinical and translational medicine（2023）

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摘要

These findings elucidate molecular mechanisms linking necroptosis to the STING pathway, and suggest a potential benefit of therapeutic targeting of necroptosis in STING-driven inflammatory diseases.

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关键词

amplifies sting pathway,ripk3–mlkl

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