ER stress aggravates diaphragm weakness through activating PERK/JNK signaling in obesity hypoventilation syndrome.

Xiaoxin Xiang,Yanhua Zhu,Xuya Pan, Wei Xin,Jianning Chen,Weijian Tang,Ruomi Guo, Wu Yuan,Xuemin He,Li Zhou,Zhitao Ren,Siying Wen,Heting Wang,Yan Lu,Shasha Li, Tufeng Chen, Yuqi Zhou,Zulin Dou,Mengyin Cai,Xiaoyue Zhang,Yanming Chen,Guojun Shi

Obesity (Silver Spring, Md.)（2023）

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摘要

These data suggest that ectopic lipid deposition impairs the diaphragmatic function of people with obesity. Activation of PERK/JNK signaling is involved in the pathogenesis of lipotoxicity-induced diaphragm weakness in obesity hypoventilation syndrome.

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