Liquid biopsies with circulating plasma HPV-DNA measurements - a clinically applicable surveillance tool for HPV-positive oropharyngeal cancer patients.

Kathrine K Jakobsen,Simone K Bendtsen,Niels Pallisgaard,Jeppe Friborg,Giedrius Lelkaitis,Christian Grønhøj,Christian von Buchwald

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

Our study, comprising the largest study of HPV+/p16+ OPSCC patients, using an ultrasensitive multiplex HPV gene panel, revealed a high sensitivity of cfHPV-DNA detection in the liquid biopsies. We recommend serial plasma HPV samples for clinical monitoring of HPV+/p16+ OPSCC patients.

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