Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates.

Henry P Foote,Huali Wu, Stephen J Balevic,Elizabeth J Thompson,Kevin D Hill,Eric M Graham,Christoph P Hornik,Karan R Kumar

Congenital heart disease（2023）

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摘要

Pro-inflammatory IL-6, but not MP exposure, was associated with post-operative organ dysfunction, suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical outcomes. Prospective study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants.

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methylprednisolone exposure,cardiopulmonary bypass,pharmacokinetic modeling,safety outcomes

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