Dexamethasone affects human fetal adrenal steroidogenesis and subsequent ACTH response in an ex vivo culture model.

Cecilie Melau,Berta Gayete Mor,Malene Lundgaard Riis,John E Nielsen,Eva Dreisler,Kasper Aaboe,Pia Tutein Brenøe,Lea Langhoff Thuesen,Kristine Juul Hare,Rod T Mitchell,Hanne Frederiksen,Anders Juul,Anne Jørgensen

Frontiers in endocrinology（2023）

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摘要

The observed effects suggest that prenatal DEX-treatment can cause direct effects on HFA steroidogenesis and in the subsequent response to ACTH-stimulation. This may indicate a requirement for careful monitoring of adrenal function in prenatally DEX-treated neonates, with particular focus on their mineralocorticoid levels.

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human fetal adrenal steroidogenesis,dexamethasone,subsequent acth response,vivo culture model

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