Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy

Dandan Wang,Wenxing Gu,Weiliang Chen,Jin Zhou,Le Yu,Byung Kook Kim,Xuenong Zhang,Jong Seung Kim

Coordination Chemistry Reviews（2022）

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摘要

•Various kinds of engineering nanovaccine which could induce immune responses for cancer immunotherapy are discussed.•The barriers and solutions in exocellular and intracellular delivery of antigen have been accentuated.•The clinical practice of nanovaccine has been proposed for application and therapeutic benefits.•Advantages and challenges to use nanovaccine are discussed with highlighting future possibilities.

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关键词

TIL,PRRs,MCs,DCs,MHC I,MHC II,CAR-T,αPD-l,αPD-L1,APCs,IL,TNF-α,OVA,TAAs,IMQ,αCTLA-4,CTLs,MPLA,PLGA NPs,BSA,IFN,HSPCs,AML,ACT,ATRA,TCR,CPP,PEI,PLA,PGA,OVA,SA,STING,CaP,ODN,TNBC,CML,Esp8,MDP,FRβ,TAMs,siRNA,TLR,Poly(I:C),MR,PLL,BMMCs,CCR22,BMDCs,DSPE,PEG,MDSCs,ICG,ICD,DOPE,PAMPs,OMVs,CLRs,RISC,Ago2,STAT3,CSCs,TRP2,EPR,Th,Tregs,MART1,MAGE-A3,PRAME

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