Preservation of β-cell function in pancreatic insufficient cystic fibrosis with highly effective CFTR modulator therapy.

Anneliese J Flatt,Saba Sheikh,Amy J Peleckis, Paola Alvarado,Denis Hadjiliadis,Darko Stefanovski,Robert J Gallop,Ronald C Rubenstein,Andrea Kelly,Michael R Rickels

The Journal of clinical endocrinology and metabolism（2023）

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摘要

ETI preserves β-cell function in CF through effects on glucose-dependent insulin secretion, proinsulin processing and meal-related insulin secretion. Further work should determine whether early intervention with ETI can prevent deterioration of glucose tolerance in PI-CF.

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关键词

Cystic fibrosis-related diabetes,cystic fibrosis transmembrane conductance regulator,highly effective modulator therapy,insulin secretion,β-cell secretory capacity

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