Comparing aspirin 75 to 81 mg vs 150 to 162 mg for prevention of preterm preeclampsia: systematic review and meta-analysis: questionable quality and small study effects?

Low-dose aspirin prevents preterm preeclampsia, but it is not innocuous. It incurs an increased risk of postpartum hemorrhage, vaginal hematomas and possibly neonatal intracranial hemorrhage. 1 Jiang Y Chen Z Chen Y et al. Aspirin use during pregnancy may be a potential risk for postpartum hemorrhage and increased blood loss: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2023; 5https://doi.org/10.1016/j.ajogmf.2023.100878 Abstract Full Text Full Text PDF Scopus (1) Google Scholar Hence, targeted treatment with the lowest effective dose is important.