Digital Twin Simulation Development and Execution on HPC Infrastructures.

The Digital Twin paradigm in medical care has recently gained popularity among proponents of translational medicine, to enable clinicians to make informed choices regarding treatment on the basis of digital simulations. In this paper we present an overview of functional and non-functional requirements related to specific IT solutions which enable such simulations - including the need to ensure repeatability and traceability of results - and propose an architecture that satisfies these requirements. We then describe a computational platform that facilitates digital twin simulations, and validate our approach in the context of a real-life medical use case: the BoneStrength application.