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NLRC5 potentiates anti-tumor CD8+ T cells responses by activating interferon-β in endometrial cancer

Jing Zhang,Bao Guo,Jia-Hua Chen, Xiao-Jing Liu,Jun-Hui Zhang,Hai-Qing Zhu,Wen-Yan Wang,Zhen-Hai Tang,Bing Wei,Yun-Xia Cao,Lei Zhan

Translational Oncology（2023）

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Abstract
•NLRC5 potentiates antitumor responses of CD8+ T cells against EC.•IFN-β promotes immunosurveillance of EC by activating CD8+ T cells.•NLRC5 potentiates antitumor responses of CD8+ T cells to EC by activating IFN-β.
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Key words
Endometrial cancer, NLR family CARD domain-containing 5,Interferon-β,CD8+ T cells,Immunotherapy
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