Associations Between Insulin-Like Growth Factor-1 and Resting-State Functional Connectivity in Cognitively Unimpaired Midlife Adults.

Tianqi Li,Colleen Pappas,Brandon Klinedinst,Amy Pollpeter,Brittany Larsen,Nathan Hoth,Faith Anton,Qian Wang,Auriel A Willette

Journal of Alzheimer's disease : JAD（2023）

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摘要

These findings suggest that sex and APOE4 genotype may modify the relationship between IGF-1 and brain network activities related to visual, motor, and cognitive processing. Additionally, IGF-1 may have an age-dependent effect on neural network connectivity.

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关键词

Alzheimer's disease, cognitive dysfunction, functional MRI, insulin-like growth factor-1

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