Endogenous erythropoietin has immunoregulatory functions that limit the expression of autoimmune kidney disease in mice.

Sofia Bin,Chiara Cantarelli,Julian K Horwitz,Micaela Gentile,Manuel Alfredo Podestà,Gaetano La Manna,Peter S Heeger,Paolo Cravedi

Frontiers in immunology（2023）

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摘要

Our data in a murine model of lupus document that endogenous EPO reduces T- and B-cell activation and autoantibody production, supporting the conclusion that EPO physiologically acts as a counterregulatory mechanism to control immune homeostasis.

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endogenous erythropoietin,autoimmune kidney disease,immunoregulatory functions

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