Specific targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptors T-cells directed against CD38 and CD138.

Jort J van der Schans,Ziyu Wang,Jennemiek van Arkel,Thijs van Schaik,Afroditi Katsarou,Ruud Ruiter, Thomas Baardemans,Huipin Yuan,Joost de Bruijn,Sonja Zweegman,Niels W C J van de Donk,Richard W J Groen,Maria Themeli,Tuna Mutis

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

We demonstrate the possibility to specifically target MM cells, even after CD38 targeted therapy, with carefully-designed dual-split CARs directed against CD38 and CD138.

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关键词

multiple myeloma,cd38,cd138,antigen,split-signaling

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