Preparation and antibacterial activities of metal complexes of norfloxacin

The metal complexes of norfloxacin were prepared,and their structures were characterized using spectroscopic techniques like IR,1H NMR,UV,atomic absorption,and CHN analysis.The solubility,melting point,and conductance measurements were also performed.These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom.The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method.It was observed that the complexes of norfloxacin with magnesium,calcium,cobalt,nickel,and copper showed improved activity compared with the stated drug.