EpCAM expression negatively regulates E-cadherin function in colorectal carcinomas.

Uchenna Simon Ezenkwa,Gabriel Olabiyi Ogun,Mbwas Isaac Mashor,Olufemi John Ogunbiyi

Ecancermedicalscience（2023）

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摘要

CRC in this study preferentially overexpress EpCAM over E-cadherin whose strong cell-cell contact inhibitory role is weakened even when expressed, resulting in further local tumour spread. This, and the observed immune response, supports targeted therapy among eligible patients.

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关键词

epcam expression,e-cadherin

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