Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats

Xiyu Gao,Dewei He,Yanting Liu,Mingchi Cui,Zhe Li,Jie Li,Yuan He,Hefei Wang,Bojian Ye,Shoupeng Fu,Dianfeng Liu

International immunopharmacology（2023）

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摘要

•LM ameliorates PD pathology in 6-OHDA-injected rats.•LM inhibits neuroinflammation in 6-OHDA-injected rats.•LM protects against 6-OHDA-induced cell damage in PC12 cells.•LM inhibits the inflammatory response in BV2 cells.•LM protects PC12 neuronal cells against microglia activation-mediated neuronal injury.

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关键词

Parkinson's disease,Limonin,Autophagy,Apoptosis,Neuroinflammation

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