Zeolites with Divalent Ions as Carriers in the Delivery of Epigallocatechin Gallate

Epigallocatechin gallate (EGCG) is a compound with veryhigh therapeuticpotential in the treatment of osteoporosis and cancer. The disadvantagesof this compound are its low stability and low bioavailability. Therefore,carriers for EGCG are sought to increase its use. In this work, newcarriers are proposed, i.e., zeolites containing divalent ions ofmagnesium, calcium, strontium, and zinc in their structure. EGCG isretained on the carrier surface by strong interactions with divalentions. Due to the presence of strong interactions, EGCG is releasedin a controlled manner from the carrier-ion-EGCG drug delivery system.The results obtained in this work confirm the effectiveness of thepreparation of new carriers. EGCG is released from the carriers dependingon the pH; hence, it can be used both in osteoporosis and in the treatmentof cancer. The divalent ion used affects the sorption and releaseof the drug. The obtained results indicate the great potential ofthe proposed carriers and their advantage over the carriers describedin the literature.