Development of a major histocompatibility complex class II conditional knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves.
bioRxiv : the preprint server for biology(2023)
摘要
A conditional MHC class II knockout mouse to study cell- and time-dependent adaptive immune responses is developed. Initial studies show microvascular endothelial cell MHC class II expression is necessary for peripheral nerve specific autoimmunity, as advocated by human adaptive immunity and transplant rejection studies.
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关键词
conditional knockout mouse,major histocompatibility,cell-specific,time-dependent
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