Wide-field Intensity Fluctuation Imaging
bioRxiv the preprint server for biology(2023)
摘要
The temporal intensity fluctuations contain important information about the light source and light -medium interaction and are typically characterized by the intensity autocorrelation function, g2(r). The measurement of g2(r) is a central topic in many optical sensing applications, ranging from stellar intensity interferometer in astrophysics, to fluorescence correlation spectroscopy in biomedical sciences and blood flow measurement with dynamic light scattering. Currently, g2(r) at a single point is readily accessible through high -frequency sampling of the intensity signal. However, two-dimensional wide -field imaging of g2(r) is still limited by the cameras' frame rate. We propose and demonstrate a 2 -pulse within -exposure modulation approach to break through the camera frame rate limit and obtain the quasi g2(r) map in wide field with cameras of only ordinary frame rates.
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关键词
Fluorescence Correlation Spectroscopy,Functional Imaging,Tissue Optical Properties
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