Promoter hypermethylation of RARB and GSTP1 genes in plasma cell-free DNA as breast cancer biomarkers in Peruvian women.

Pierina Danos,Stefano Giannoni-Luza,Alexis Germán Murillo Carrasco,Oscar Acosta,Maria Luisa Guevara-Fujita,José Manuel Cotrina Concha,Henry Guerra Miller, Joseph Pinto Oblitas, Alfredo Aguilar Cartagena, Jhahaira Araujo Soria,Ricardo Fujita,José Luis Buleje Sono

Molecular genetics & genomic medicine（2023）

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摘要

Promoter hypermethylation of RARB + GSTP1 genes is associated with breast cancer, older age, and postmenopausal Peruvian patients. The methylated promoter of the RARB + GSTP1 genes needs further validation to be used as a biomarker for liquid biopsy and as a recommendation criterion for additional tests in asymptomatic women younger than 50 years.

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关键词

breast cancer, cfDNA, GSTP1, liquid biopsy, Methylight, PMR, RARB

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