Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate.

Zhenqiu Liu,John Cologne,Sally A Amundson,Asao Noda

International journal of radiation biology（2023）

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摘要

With the proposed approach, we may identify candidate biomarkers that change monotonically in relation to dose, have a persistent transcriptional response, and are reliable over a wide dose range.

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关键词

Dosimetry biomarkers, linear mixed model, low- and high-dose irradiation, persistent transcriptional response, molecular pathways, integrated time-dose dynamics

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