Graft survival in primary thoracic organ transplant recipients: A special report from the International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation

A detailed analysis of posttransplant patient survival has been a key component of the annual reports of the International Thoracic Organ Transplant Registry. These survival analyses—published separately for adult and pediatric heart transplant (HT) and lung transplant (LT) recipients— have all analyzed patient death as the primary outcome. 1 Hayes Jr., D. Cherikh W.S. Chambers D.C. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-second pediatric lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1015-1027 Abstract Full Text Full Text PDF PubMed Scopus (82) Google Scholar , 2 Chambers D.C. Cherikh W.S. Harhay Jr., M.O. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (427) Google Scholar , 3 Rossano J.W. Singh T.P. Cherikh W.S. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-second pediatric heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1028-1041 Abstract Full Text Full Text PDF PubMed Scopus (128) Google Scholar , 4 Khush K.K. Cherikh W.S. Chambers D.C. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1056-1066 Abstract Full Text Full Text PDF PubMed Scopus (463) Google Scholar Because some transplant recipients may receive a retransplant when the transplanted organ shows signs of graft failure, retransplantation has contributed to patient survival time in these analyses. The purpose of this special Registry report is to analyze the outcome of graft survival, defined by a composite outcome of time to death or retransplantation in thoracic organ transplant recipients and thus assess how long patients survive with their primary transplant. Specifically, this report has 3 objectives: (1) to provide an estimate of graft survival (freedom from death or retransplant) in adults and children with HT or LT, (2) to describe cumulative retransplantation rates after primary transplant, and (3) to describe multivariable models of 10-year graft survival following primary transplant. Because no new patients have been added to the Registry since the 2019 report, this report presents analysis of transplant recipients previously described in the 2019 and 2021 reports 1 Hayes Jr., D. Cherikh W.S. Chambers D.C. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-second pediatric lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1015-1027 Abstract Full Text Full Text PDF PubMed Scopus (82) Google Scholar , 2 Chambers D.C. Cherikh W.S. Harhay Jr., M.O. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (427) Google Scholar , 3 Rossano J.W. Singh T.P. Cherikh W.S. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-second pediatric heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1028-1041 Abstract Full Text Full Text PDF PubMed Scopus (128) Google Scholar , 4 Khush K.K. Cherikh W.S. Chambers D.C. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transpl. 2019; 38: 1056-1066 Abstract Full Text Full Text PDF PubMed Scopus (463) Google Scholar , 5 Singh T.P. Cherikh W.S. Hsich E. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-fourth pediatric heart transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transpl. 2021; 40: 1050-1059 Abstract Full Text Full Text PDF PubMed Scopus (21) Google Scholar , 6 Chambers D.C. Perch M. Zuckermann A. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult lung transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transpl. 2021; 40: 1060-1072 Abstract Full Text Full Text PDF PubMed Scopus (146) Google Scholar , 7 Hayes Jr., D. Harhay M.O. Cherikh W.S. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: twenty-fourth pediatric lung transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transpl. 2021; 40: 1023-1034 Abstract Full Text Full Text PDF PubMed Scopus (16) Google Scholar , 8 Khush K.K. Hsich E. Potena L. et al. International Society for H and Lung TThe International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: thirty-eighth adult heart transplantation report - 2021; focus on recipient characteristics. J Heart Lung Transpl. 2021; 40: 1035-1049 Abstract Full Text Full Text PDF PubMed Scopus (87) Google Scholar and is based on data submitted to the Registry through early 2019.