Galectin-targeting glycocalix[4]arenes can enter the cells.

Miluše Vlachová,Van Nguyen Tran,Jakub Červený,František Dolníček,Lucie Petrásková,Helena Pelantová,Ondřej Kundrát,Josef Cvačka,Zuzana Bosáková,Vladimír Křen,Pavel Lhoták,Jitka Viktorová,Pavla Bojarová

Chemical communications (Cambridge, England)（2023）

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摘要

Elevated levels of galectin-3 are associated with tumorigenesis. Its inhibition with high-affinity carbohydrate ligands opens new therapeutic routes. Targeting of intracellular galectin-3 is challenging for polar inhibitors like carbohydrates. We demonstrate the potential of novel biomedical research tools, glycocalix[4]arenes, to enter epithelial cells, which may allow their interaction with galectin-3.

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cells,galectin-targeting

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