Multiwalled Carbon Nanotubes Decorated with Mn_0.5Zn_0.5Fe₂O₄ Nanoparticles for Magneto-Photothermal Cancer Therapy

Alternative cancer treatments such as photothermal therapy(PTT)and magnetic hyperthermia (MHT) techniques have been studied to showpromising potential as supplementary modalities. However, such techniqueshave their own limitations; for instance, highly concentrated intratumoralinjections of magnetic nanoparticles are required to compensate theirlow specific loss power under safe and low magnetic field intensityfor the MHT, while the PTT has limitations in the treatment of deep-seatedtumors due to low light penetration. Here, the decoration of the multi-walledcarbon nanotube (MWCNT) surface by magnetic nanoparticles (& AP;8.5nm) was achieved by a hydrothermal method and the development of MWCNT/Mn0.5Zn0.5Fe2O4 (MZFC) hybridsfor magneto-photothermal dual-mode cancer therapy. The obtained specificloss power of the MZFC hybrids is found to be at least 1 order ofmagnitude higher, with improvement from & SIM;19 W/g to 225 W/g,under the excitation of both an AMF with a magnetic field intensityof 6.4 kA/m and a frequency of 300 kHz and a simultaneous NIR laserof 0.5 W/cm(2) irradiation. The synergistic utilization ofthe photothermal and magnetic properties of MZFC effectively diminishesthe required magnetic field amplitude and NIR laser power density.Our in vitro cell experiments confirmed that the thermal effects mediatedby the MZFC after endocytosis delivered enhanced cytotoxicity in thepresence of dual excitation of NIR laser and AMF. These findings indicatethat MZFC nanohybrids possess significant potential as targeted nanoheatingagents for hyperthermia applications.