Nitrogen-Doped Carbon Dots with Oxidation Stress Protective Effects for Reactive Oxygen Species Scavenging on Hepatic Ischemia-Reperfusion Injury

Hepatic ischemia-reperfusion injury (HIRI), whichis a commonpathophysiological process that occurs in hepatectomy, affects thesurvival and prognosis of patients. In this study, we synthesizedchitosan-derived nitrogen-doped carbon dots (CNDs) with reactive oxygenspecies (ROS) scavenging capabilities and applied them in the preventionof HIRI. CNDs demonstrated scavenging ability against ROS, particularlyhydroxyl radicals. Our results show that CNDs can alleviate liverdamage in mice, suppress the inflammatory response, and inhibit apoptosistriggered by liver ischemia/reperfusion (I/R) operation. Mechanistically,CNDs exhibit hepatoprotective effects on I/R injury due to the clearanceof ROS. In summary, CNDs protect the liver against ischemia-reperfusioninjury by suppressing oxidative stress damage.