Prevalence of MLSB Phenotypes of Staphylococcus aureus isolates in a tertiary care hospital of Delhi

Against the backdrop of the ever-chang-ing Staphylococcal resistance pattern, clin-damycin remains a viable therapeutic alter-native Variation of Clindamycin drug resis-tance patterns with geographic area make inducible clindamycin resistance testing imperative for all staphylococcal isolates to avoid therapeutic failure. This was a prospective study conducted over a period of 1.5 years from January 2021 until June 2022. Prevalence of different MLSB Phenotypes of Staphylococcus aureus iso-lates was determined by standard disc diffu-sion method as per CLSI guidelines. Pyogenic samples received in the Microbiology lab that yielded Staphylococcus aureus were further tested for the presence of clindamycin resistance by disc diffusion method. Out of 6586 total pyogenic and respiratory specimens received in the lab, Staphylococcus aureus was yielded in 752 samples. On further test-ing for the MLSB phenotypes, 16.3% iso-lates were found to be iMLSB, 19.28% were cMLSB, 43.1% were of MSB type. ICR screening will reduce the unessential sub-jection of the patient to the antibiotic, and would prevent unnecessary adverse effects in the patients.