Vitamin D has no significant associations with high sensitivity C reactive protein and tumor necrosis factor-alpha in adults with prediabetes br

Objective: Both vitamin D deficiency (VDD) and meta-inflammation are common in patients with prediabetes. The aim of this study was to see the association of vitamin D with inflammatory markers: high-sensitivity C reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-& alpha;) in adults with prediabetes.Methods: This cross-sectional study included 115 newly detected adults with prediabetes [age (years): 36.37 & PLUSMN;10.06, m/f: 23/92, BMI (kg/m2): 28.81 & PLUSMN;4.34]. Clinical information was collected and blood was taken in a fasting state to measure vitamin D by high-performance liquid chromatography, hs-CRP by turbidimetric/immunoturbidimetric, and TNF-& alpha; by ELISA method.Results: About 46.09% had VDD (<20 ng/mL), 33.04% had vitamin D insufficiency (20-29.9 ng/mL) and 60.87% had high cardiovascular risk (hs-CRP & GE;3.0 mg/L) and 92.17% had high inflammatory status (TNF-& alpha; & GE;2.53 pg/mL). Both hs-CRP and TNF-& alpha; levels were statistically similar across the vitamin D status (NS for both). Regression analyses showed that both hs-CRP and TNF-& alpha; had no predictive associations with either vitamin D level or status in adults with prediabetes (NS for both).Conclusion: Vitamin D had no significant association with hs-CRP and TNF-& alpha; in adults with prediabetes.