Physical activity attenuated the negative effects of obesity on chronic disease-free life expectancy in rural adults

Aim This study aimed to estimate the chronic disease-free life expectancy (CDFLE) for distinct joint phenotypes of physical activity and obesity defined by six indicators in resource-limited areas. Subject and methods In this study, a total of 38,789 participants aged 18 to 79 were recruited from the Henan rural cohort study. Logistic regression analysis was applied to assess the independent and combined effects of obesity and physical activity on chronic disease. The CDFLE according to obesity indicators and physical activity was measured via the Sullivan method. Results Compared to participants who were physically active and nonobese defined by BMI, the multivariable-adjusted OR (95% CI) of the risk for prevalent chronic disease was 2.024 (1.833, 2.236) among those with obesity and physical inactivity, and the corresponding estimate for obese but physically active participants was 1.684 (1.550, 1.829). Compared with nonobese and physically active individuals, those with physical inactivity plus obesity classified by BMI, waist circumference, waist-to-hip ratio, waist-to-height ratio, body fat percent, and visceral fat index lost 4.42 (2.73, 6.12), 4.10 (2.95, 5.25), 4.84 (3.69, 5.98), 4.59 (3.47, 5.70), 3.86 (2.59, 5.13), and 3.81 (2.63, 4.99) years of CDFLE at age 50, respectively. The corresponding estimates for those who were obese but physically active were 2.75 (0.78, 4.72), 2.64, (1.43, 3.85), 3.14 (1.99, 4.30), 3.23 (2.09, 4.38), 2.22 (0.96, 3.48), and 1.85 (0.66, 3.03) years. Conclusion Healthy body weight and physical activity were beneficial for chronic disease and CDFLE, and physical activity attenuated the negative effects of obesity.