Analysis of 2D and 3D Convolution Models for Volumetric Segmentation of the Human Hippocampus

Extensive medical research has revealed evidence of a strong association between hippocampus atrophy and age-related diseases such as Alzheimer's disease (AD). Therefore; segmentation of the hippocampus is an important task that can help clinicians and researchers in diagnosing cognitive impairment and uncovering the mechanisms behind hippocampal changes and diseases of the brain. The main aim of this paper was to provide a fair comparison of 2D and 3D convolution-based architectures for the specific task of hippocampus segmentation from brain MRI volumes to determine whether 3D convolution models truly perform better in hippocampus segmentation and also to assess any additional costs in terms of time and computational resources. Our optimized model, which used 50 epochs and a mini-batch size of 2, achieved the best validation loss and Dice Similarity Score (DSC) of 0.0129 and 0.8541, respectively, across all experiment runs. Based on the model comparisons, we concluded that 2D convolution models can surpass their 3D counterparts in terms of both hippocampus segmentation performance and training efficiency. Our automatic hippocampus segmentation demonstrated potential savings of thousands of clinician person-hours spent on manually analyzing and segmenting brain MRI scans