Concurrent PIEZO1 activation and ATP2B4 blockade effectively reduce the risk of cerebral malaria and inhibit in vitro Plasmodium falciparum multiplication in red blood cells.

Mathieu Adjemout,Bruno Pouvelle,Fatou Thiam, Alassane Thiam,Magali Torres, Samia Nisar,Babacar Mbengue,Alioune Dieye,Pascal Rihet,Sandrine Marquet

Genes & diseases（2023）

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摘要

Malaria caused by the Plasmodium falciparum parasite is responsible for more than 240 million cases per year and killed 627,000 people in 2020,mostly African children.The malaria parasite is transmitted by mosquitos belonging to the genus Anopheles.

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