Report on the 10 cases of allergic reactions to oxaliplatin

Objective The aim of this study was to investigate the mechanism, clinical manifestations, prevention and treatment measures of allergic reactions caused by oxaliplatin. Methods Made detailed data about allergic reactions to oxaliplatin from 10 patients in our department, and made analysis and discussions about it while referring to related reference. Results All the 10 patients had no history of allergies, 4 cases of allergies occurred during the course of multi-cycle chemotherapy, and 6 cases occurred on the first time of drug administration, whose allergic symptoms were present in the process of using oxaliplatin, with the infusion time from 10 to 25 min. When relevant treatments such as drug withdrawal, hormone, intravenous calcium gluconate and magnesium sulfate were done to the patients, related symptoms could be soon relieved. Conclusion Mechanisms of oxaliplatin allergic are still unclear. Applying calcium and magnesium may reduce the risk of neurotoxicity and reduce the degree of allergic reactions before administration of oxaliplatin.