Structural basis of the specificity of USP18 toward ISG15

Anja Basters,Paul P Geurink,Annika Röcker,Katharina F Witting,Roya Tadayon,Sandra Hess,Marta S Semrau,Paola Storici,Huib Ovaa,Klaus-Peter Knobeloch,Günter Fritz

Nature Structural & Molecular Biology（2017）

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摘要

The specificity of USP18's deconjugating activity toward ISG15, a ubiquitin-like protein induced by interferon, is revealed by structural and biochemistry studies of the mouse proteins.

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