Employing Nano-Snfe2o4 in the Synthesis of Arylbenzimidazoles, the Computational Study of the Reaction Mechanism, and Examining the Products As Putative Human Transmembrane Protein Activators

In this work, the efficient and green method has been presented to prepare arylbenzimidazoles via an aqueous, one-pot reaction. The products were obtained using the reaction between aldehydes, malononitrile, and 1,2-phenylenediamine in water as a solvent at room temperature. SnFe2O4 nanoparticles were used as the heterogeneous catalyst at room temperature under an inert atmosphere. The morphology and composition of the catalyst have been defined by SEM, XRD, UV–Vis, FTIR, and Raman spectroscopy. Ten different arylbenzimidazoles were prepared in 70–98