Synthesis and antiplatelet activity of 2-substituted imidazolines

2-Substituted 4,5-dihydro-1 H -imidazoles were synthesized by the condensation of aromatic carboxylic acids with ethylenediamine in the presence of KU-2/8 cation-exchange resin as a catalyst. Subsequent alkylation of the resulting compounds with 2-chloromethyl- gem -dichlorocyclopropane or 2-bromomethyl-1,3-dioxolane gave previously unknown substituted imidazolines containing carbo- and heterocyclic fragments. The synthesized 2-substituted 4,5-dihydro-1 H -imidazoles were found to possess the antiplatelet activity at the level of acetylsalicylic acid.