Photoinduced radical cascade domino Heck coupling of N -aryl acrylamide with vinyl arenes enabled by palladium catalysis.

Here, a redox-neutral palladium-catalyzed photo-induced radical cascade domino Heck reaction of -aryl acrylamide with vinyl arenes is described. A diverse range of bioactive oxindoles, featuring an all-carbon quaternary center, were synthesized. The reaction is proposed to proceed an open-shell intermediate and occurs under mild reaction conditions, exhibiting excellent functional group tolerance. Importantly, the synthesized products can be readily transformed into biologically active molecules, including (±)-physostigmine and (±)-physovenine.