Iron in multiple sclerosis – Neuropathology, immunology, and real-world considerations

Bettina Zierfuss, Zitong Wang, Alexandra N. Jackson,Dorsa Moezzi,V．Wee Yong

Multiple sclerosis and related disorders（2023）

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摘要

•Iron accumulation shapes microglia phenotype and disability in MS.•Iron-laden rims at lesion edges expand faster than non-iron rims in MS.•Ferroptosis is linked to T cell activation-mediated neurodegeneration in MS models.•Iron levels control B cell immunity and may play a role in MS pathophysiology.•Modulation of Nrf2 pathway may aid to overcome iron cytotoxicity in MS.

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关键词

Magnetic resonance imaging,Dietary iron,Immune cells,Oxidative stress,Antioxidants,Iron chelators

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