Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.

Ai-Ci Chan, Pei-Ya Shan,Men-Hsin Wu,Pin-Han Lin,Chang-Shun Tsai,Chia-Chien Hsu,Ting-Hsiang Chiu,Ting-Wei Hsu,Yi-Cheun Yeh,Yun-Ju Lai,Wei-Min Liu,Ling-Hsien Tu

Chemical communications (Cambridge, England)（2023）

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摘要

Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.

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关键词

piperic acid derivative,antimicrobial activity,iapp aggregation process,molecular modulator

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