Loss of normal Alzheimer's disease-associated Presenilin 2 function alters antiseizure medicine potency and tolerability in the 6-Hz focal seizure model.

Frontiers in neurology（2023）

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摘要

Acute ASM potency and tolerability in the high-throughput 6-Hz test may be significantly altered with loss of normal PSEN2 function. Seizures in discrete EOAD populations may benefit from precisely selected medicines optimized for primary ASM pharmacological mechanisms.

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perampanel, levetiracetam, gabapentin, lamotrigine, valproic acid, mouse seizure model, piriform cortex, cFos

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